Cell. May interact with a number of other medications including those metabolized by hepatic enzymes CYP 3A4, clarithromycin, protease inhibitors, cyclosporine, gemfibrozil, oral contraceptives, and digoxin. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Initially, this needs further investigating to rule out more serious muscle effects (such as rhabdomyolysis - the destruction of muscle cells). For a complete list of all side effects, click here. | Drugs. Nasopharyngitis (swelling of the nasal passages and back of the throat), arthralgia (joint pain), diarrhea, dyspepsia, pain, and urinary tract infections. Follow your doctor's orders or the directions on the label. Blood samples were collected after a 12-hour fasting period and serum lipoprotein levels were measured at baseline and after four weeks. Am J Health Syst Pharm. 2016 Nov 26;11(11):CD009462. Do not drink large amounts of alcohol with atorvastatin. age of 57.8 +/- 7.8 years and 58.5 +/- 7.8 years for the morning and evening administration groups, respectively. NIH If a statin has a half life of less than 6 … All patients were male outpatients with a mean +/- S.D. (2) Even if properly counseled to take statins with a shorter half-life at bedtime, some patients do not comply which may result in decreased efficacy. Izquierdo-Palomares JM, Fernandez-Tabera JM, Plana MN, Añino Alba A, Gómez Álvarez P, Fernandez-Esteban I, Saiz LC, Martin-Carrillo P, Pinar López Ó. Cochrane Database Syst Rev. Get the latest public health information from CDC: https://www.coronavirus.gov. Statins - cholesterol-lowering drugs - (e.g. Take once daily. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. So that’s why some Statins must be taken at night but Atorvastatin can be taken at any time as long as it’s the same time each day. Efficacy of alternate-day dosing versus daily dosing of atorvastatin. Harris KP, Wheeler DC, Chong CC; Atorvastatin in CAPD Study Investigators. the elimination half-lives of atorvastatin, pravastatin and rosuvastatin are significantly longer than that of simvastatin and this is probably significant in the ability to take these other statins in the morning with non-significant changes in lipid lowering compared to evening administration: half-lives Guan D, Xiong Y, Borck PC, Jang C, Doulias PT, Papazyan R, Fang B, Jiang C, Zhang Y, Briggs ER, Hu W, Steger D, Ischiropoulos H, Rabinowitz JD, Lazar MA. Common medications that may interact with atorvastatin include: Note that this list is not all-inclusive and includes only common medications that may interact with atorvastatin. The elimination half-life of statins, or the amount of time it takes for half the dose to leave your body, determines if the drug should be taken in the evening when the cholesterol-making enzyme is more active, or if it can be taken anytime. Take atorvastatin exactly as directed by your doctor. Epub 2018 Jul 26. doi: 10.1002/14651858.CD008226.pub2. Please enable it to take advantage of the complete set of features! 2002 Apr;61(4):1469-74. doi: 10.1046/j.1523-1755.2002.00262.x. Methods: Alternatively, the longer half-lives of rosuvastatin, atorvastatin, pitavastatin, and pravastatin allow these agents to maintain a therapeutic drug concentration over a 24-hour period and allow alternate administration times. The dosage of atorvastatin needs to be individualized but initially should start at 10-20 mg/day and be guided by the results of cholesterol tests taken 2 to 4 weeks later. Drugs.com https://www.drugs.com/ppa/atorvastatin.html. The authors recommend that people using long-acting statins take them at a time of day that is easy for them to remember. Jafari M, Ebrahimi R, Ahmadi-Kashani M, Balian H, Bashir M. J Cardiovasc Pharmacol Ther. Chronotherapy versus conventional statins therapy for the treatment of hyperlipidaemia. Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Results: Of the 204 hyperlipidemic patients receiving atorvastatin, 64 met the inclusion criteria and were enrolled in the study, 32 of whom took the drug in the morning (before noon) and an equal number who took the drug at night (after 6 p.m. but before midnight). Statin Dosing Instructions, Medication Adherence, and Low-Density Lipoprotein Cholesterol: a Cohort Study of Incident Statin Users. Atorvastatin: an updated review of its pharmacological properties and use in dyslipidaemia. doi: 10.1002/14651858.CD009462.pub2. Medicines that interact with atorvastatin may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with atorvastatin. Atorvastatin is also known as an HMG-CoA reductase inhibitor. People aged older than 65, taking certain medications (for example cyclosporine, itraconazole, HIV antivirals), who drink more than two alcoholic drinks per day or with kidney disease appear more at risk of serious side effects. Are Statin Side Effects 'All in Your Head'? Select one or more newsletters to continue. Atorvastatin. Of the 204 hyperlipidemic patients receiving atorvastatin, 64 met the inclusion criteria and were enrolled in the study, 32 of whom took the drug in the morning (before noon) and an equal number who took the drug at night (after 6 p.m. but before midnight). COVID-19 is an emerging, rapidly evolving situation. This includes people with pre-existing coronary heart disease, diabetes, peripheral vessel disease, a previous history of stroke and stroke-like events or heart attack, or with multiple risk factors (such as older age, smoking, high blood pressure, low HDL-C, family history of heart disease). 2017 Aug 1;24(8):841-852. doi: 10.5551/jat.36335. Copyright 1996-2020 Drugs.com. You can generally take atorvastatin at a time of day to suit you, but it is best to take your doses at the same time of day each day. | A placebo-controlled trial examining atorvastatin in dyslipidemic patients undergoing CAPD. Take this medicine at the same time each day. Results: doi: 10.1016/j.cell.2018.06.031. Maximal blood pressure values were significantly (P = 0.01) decreased by both treatment regimens, whereas nightly minimum values remained unchanged. The early morning rise in blood pressure was decreaseed after morning and … USA.gov. 2001;61(12):1835-81. doi: 10.2165/00003495-200161120-00012. Atorvastatin also boosts the breakdown of lipids. Cochrane Database Syst Rev. In usual clinical practice, statins are given once per day, without specifying the time when they should be taken. Timing of Administration: For Commonly-Prescribed Medicines in Australia. The dosage of atorvastatin needs to be individualized but initially should start at 10-20 mg/day and be guided by the results of cholesterol tests taken 2 to 4 weeks later. Medication Adherence Improvement By Using Administration Timing Simplification Protocol (ATSP) in Cardiovascular Disease Patients. Clipboard, Search History, and several other advanced features are temporarily unavailable. NLM Patients were excluded if they had diseases or conditions or took medication known to affect serum lipoprotein levels, as were patients who consumed more than three alcoholic drinks per day and those who could not verify the time of atorvastatin administration. Do not increase or decrease the dosage without his or her advice. May also affect some diabetes markers (such as HbA1c or fasting glucose), and may not be suitable in those with liver or kidney disease, or those who have recently had a stroke or a TIA (transient ischemic attack). The following information includes only the average doses of this medicine. Possibly more effective than other statins. Seek urgent medical advice and consider temporarily withholding atorvastatin if you develop any acute muscle pain or have another condition that may increase your risk of serious muscle injury or kidney failure such as a severe infection, major surgery, trauma, uncontrolled seizures, severe electrolyte or metabolic disorders. Avoid drinking large quantities of grapefruit juice or eating grapefruit or grapefruit products while taking atorvastatin. Continuous ambulatory peritoneal dialysis. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use atorvastatin only for the indication prescribed. May be taken at any time of the day (morning or night); however, it is best to be consistent with the time you take your tablets. Conclusion: If your dose is different, do not change it unless your doctor tells you to do so.The amount of medicine that you take depends on the strength of the medicine. daily by their primary care physician were interviewed by a clinical pharmacist in the ambulatory care clinic for study enrollment. The dose of this medicine will be different for different patients. All patients were male outpatients with a mean ± S.D. 2016 Apr 15;8(2):13. doi: 10.3390/pharmaceutics8020013. You can take the tablets either before or after food. Speak to your doctor about how drug interactions should be managed. Atorvastatin should not be taken during pregnancy or while breastfeeding. Do not break, crush, or chew it. Epub 2019 Jul 31. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. All patients were male outpatients with a mean ± S.D. Patients whose care was managed by a teaching hospital run by the Department of Veterans Affairs who were prescribed atorvastatin calcium 40 mg p.o. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Changes in the levels of total cholesterol, low-density-lipoprotein cholesterol, triglycerides, and high-density-lipoprotein cholesterol were similar among hyperlipidemic patients receiving atorvastatin calcium 40 mg, regardless of the time of day the drug was administered. Do not increase or … Muscle pain, tenderness, or weakness. Ensure you use effective contraception while taking atorvastatin if you are a woman of childbearing age and talk to your doctor if you intend to become pregnant before you actually become pregnant. These symptoms typically resolve with discontinuation. Revision date: June 10, 2020. Plan to do exercise regularly and stop smoking if you smoke. Some Statins only last a few hours in your system but Atorvastatin lasts 14 hours. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. You should refer to the prescribing information for atorvastatin for a complete list of interactions. Atorvastatin is also used to lower the risk of coronary events (such as a heart attack, stroke, or angina) in patients at high risk of these events. Kaur G, Phillips CL, Wong K, McLachlan AJ, Saini B. Pharmaceutics. Effectiveness of rosuvastatin versus atorvastatin in reducing lipid levels and achieving low-density-lipoprotein cholesterol goals in a usual care setting. Bullano MF, Kamat S, Wertz DA, Borok GM, Gandhi SK, McDonough KL, Willey VJ. If you forget to take a dose of atorvastatin don't worry, just leave out the missed dose and take your next dose as usual when it is due. J Atheroscler Thromb. 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